Recent advances in N-heterocyclic carbene (NHC)-catalysed benzoin reactions

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Recent advances in N-heterocyclic carbene (NHC)-catalysed benzoin reactions

N-Heterocyclic carbenes (NHCs) have emerged as a powerful class of organocatalysts that mediate a variety of organic transformations. The Benzoin reaction constitutes one of the earliest known carbon-carbon bond-forming reactions catalysed by NHCs. The rapid growth of NHC catalysis in general has resulted in the development of a variety of benzoin and benzoin-type reactions. An overview of such...

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N-heterocyclic carbene catalysed asymmetric cross-benzoin reactions of heteroaromatic aldehydes with trifluoromethyl ketones.

A new triazolium salt derived N-heterocyclic carbene catalyses an asymmetric cross-benzoin-type reaction of heteroaromatic aldehydes and various trifluoromethyl ketones in good to excellent yields (69-96%) and moderate to good enantioselectivities (ee = 39-85%). Up to 99% ee can be achieved by recrystallisation.

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ژورنال

عنوان ژورنال: Beilstein Journal of Organic Chemistry

سال: 2016

ISSN: 1860-5397

DOI: 10.3762/bjoc.12.47